The Crystal Structure of Fulvine: A Pyrrolizidine Alkaleid
نویسنده
چکیده
Ecarts-type sur les angles 0,1 ° 0(6") -K(1)-O(C) 87,7 ° 0(6 l) -K(2)-O(5 Iv) 105,7 ° 0(6") -K(I)-O(7 v~) 101,0 0(6/) -K(2)-O(10 147,6 0(6") -K(1)-O(2 TM) 72,1 (3(6/) -K(2)-O(3") 75,5 0(6") -K(1)-O(3 i) 79,0 0(6/) -K(2)W '1 80,4 O(4)--K(1)-O(7 ~") 82,7 0(30 -K(2)-O(I v) 51,2 O(4)--K(1)-O(C) 95,6 O(30-K(2)-O(5t0 80,0 O(4)--K(1)-O(3 ~ ) 9 7 , 5 O(30-K(2)W ~t 74,2 O(4)--K(i)-O(5) 50,0 O(30-K(2)-O(3 ~l) 81,2 O(5)--K(1)-O(7 ~t~) 1 0 5 , 5 O(5~0-K(2)-O(10 102,6 O(5)--K(1)-O(2 ~i ) 7 3 , 7 O(5~0-K(2)W v~ 68,5 O(5)--K(1)-O(3 ~ ) 7 6 , 7 O(3~)-K(2)-O(10 92,9 O(7~H)-K(1)-O(6 i ) 103,3 O(3")-K(2)W '~ 71,8 O(7~)-K(1)-O(2 ~") 68,7 0(3 H ) -K(1)-O(6 i) 73,8 0(3 ~) -K(1)-O(2"") 114,0
منابع مشابه
Effect of fulvine on pulmonary arteries and veins of the rat.
Wagenvoort, C. A., Wagenvoort, N., and Dijk, H. J. (1974). Thorax, 29, 522-529. Effect of fulvine on pulnonary arteries and veins of the rat. Fulvine, one of the pyrrolizidine alkaloids from the Crotalaria group, was administered to rats in a single dose. Vasoconstriction and medial hypertrophy of pulmonary arteries and right ventricular hypertrophy developed gradually, starting after one week....
متن کاملFulvine and the pulmonary circulation.
The pyrrolizidine alkaloid, fulvine, is now accepted as a major cause of veno-occlusive disease of the liver in the West Indies, where it is ingested as a decoction of the plant Crotalaria fulva in bush tea. Fulvine is similar in chemical structure to monocrotaline, which is known to cause pulmonary hypertension in rats. Thirty young female rats were given a single dose of fulvine either by int...
متن کاملHaemodynamic studies in veno-occlusive disease of the liver.
Haemodynamic studies in 8 tribal patients from central India with veno-occlusive disease of the liver are reported. The disease was caused by eating cereals contaminated with seeds of a crotalaria species rich in toxic pyrrolizidine alkaloids similar to monocrotaline and fulvine. All patients showed raised hepatic venous wedge pressures and pressure gradients between hepatic venous wedge and fr...
متن کاملElectron microscopy of pulmonary vasculature after application of fulvine.
Wagenvoort, C. A., Dingemans, K. P., and Lotgering, G. G. (1974). Thorax, 29, 511-521. Electron microscopy of pulmonary vasculature after application of fulvine. This is an electron microscopic study of the effect of fulvine on the pulmonary arteries and veins of the rat. Marked constriction of the arteries was evident from excessive crenation of the interial elastic membrane, resulting in sque...
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Objective- Breast cancer is one of the most serious problems in oncology. Alkaloids pyrrolizidine are widely found in nature and exhibited versatile biological activities. The aim of the present study was to assess anti-tumor activity of methyl 1,3-dioxo-1,1',2',3,5',6',7',7a'-octahydrospiro[indene-2,3'-pyrrolizidine]-2'-carboxylate (6) on 7,12 dimethylbenz(a) anthracene (DMBA)-induced mammary ...
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